P04.74 Preclinical evaluation of combinations targeting the DNA damage response in 2D and 3D models of glioblastoma stem cells

BACKGROUND: Despite surgical resection followed by DNA-damaging adjuvant therapies, glioblastoma remain incurable. Increasing evidence demonstrates that aberrations within the DNA damage response (DDR) of cancer stem cells contribute to treatment resistance. We have previously shown that the Fanconi...

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Библиографические подробности
Опубликовано в: :Neuro Oncol
Главные авторы: Rominiyi, O, Gomez-Roman, N, Lad, N, Al-Tamimi, Y, Jellinek, D A, Chalmers, A J, Carroll, T A, Chen, B, Collis, S J
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2018
Предметы:
Poster Presentations
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144133/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy139.308
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