A high throughput screen for next-generation leads targeting malaria parasite transmission

Spread of parasite resistance to artemisinin threatens current frontline antimalarial therapies, highlighting the need for new drugs with alternative modes of action. Since only 0.2–1% of asexual parasites differentiate into sexual, transmission-competent forms, targeting this natural bottleneck pro...

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Publicat a:Nat Commun
Autors principals: Delves, Michael J., Miguel-Blanco, Celia, Matthews, Holly, Molina, Irene, Ruecker, Andrea, Yahiya, Sabrina, Straschil, Ursula, Abraham, Matthew, León, María Luisa, Fischer, Oliver J., Rueda-Zubiaurre, Ainoa, Brandt, Jochen R., Cortés, Álvaro, Barnard, Anna, Fuchter, Matthew J., Calderón, Félix, Winzeler, Elizabeth A., Sinden, Robert E., Herreros, Esperanza, Gamo, Francisco J., Baum, Jake
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143625/
https://ncbi.nlm.nih.gov/pubmed/30228275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05777-2
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