Development of a novel UHPLC-MS/MS-based platform to quantify amines, amino acids and methylarginines for applications in human disease phenotyping

Amine quantification is an important strategy in patient stratification and personalised medicine. This is because amines, including amino acids and methylarginines impact on many homeostatic processes. One important pathway regulated by amine levels is nitric oxide synthase (NOS). NOS is regulated...

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Udgivet i:Sci Rep
Main Authors: Ahmetaj-Shala, Blerina, Olanipekun, Michael, Tesfai, Abel, MacCallum, Niall, Kirkby, Nicholas S., Quinlan, Gregory J., Shih, Chih-Chin, Kawai, Ryota, Mumby, Sharon, Paul-Clark, Mark, Want, Elizabeth J., Mitchell, Jane A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143519/
https://ncbi.nlm.nih.gov/pubmed/30228360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31055-8
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