Association of ERBB Mutations With Clinical Outcomes of Afatinib- or Erlotinib-Treated Patients With Lung Squamous Cell Carcinoma: Secondary Analysis of the LUX-Lung 8 Randomized Clinical Trial

IMPORTANCE: Treatment choice for lung squamous cell carcinoma could be aided by identifying predictive biomarkers. OBJECTIVE: To assess whether patient outcomes in the LUX-Lung 8 trial were associated with ERBB gene family member aberrations in tumor specimens. DESIGN, SETTING, AND PARTICIPANTS: Ad...

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Detalhes bibliográficos
Publicado no:JAMA Oncol
Main Authors: Goss, Glenwood D., Felip, Enriqueta, Cobo, Manuel, Lu, Shun, Syrigos, Konstantinos, Lee, Ki Hyeong, Göker, Erdem, Georgoulias, Vassilis, Li, Wei, Guclu, Salih, Isla, Dolores, Min, Young Joo, Morabito, Alessandro, Ardizzoni, Andrea, Gadgeel, Shirish M., Fülöp, Andrea, Bühnemann, Claudia, Gibson, Neil, Krämer, Nicole, Solca, Flavio, Cseh, Agnieszka, Ehrnrooth, Eva, Soria, Jean-Charles
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2018
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143014/
https://ncbi.nlm.nih.gov/pubmed/29902295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2018.0775
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