Biophysical analysis of sialic acid recognition by the complement regulator Factor H

Complement factor H (FH), an elongated and substantially glycosylated 20-domain protein, is a soluble regulator of the complement alternative pathway (AP). It contains several glycan binding sites which mediate recognition of α2-3-linked sialic acid (FH domain 20) and glycosaminoglycans (domains 6–8...

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Publicado en:Glycobiology
Autores principales: Schmidt, Christoph Q, Hipgrave Ederveen, Agnes L, Harder, Markus J, Wuhrer, Manfred, Stehle, Thilo, Blaum, Bärbel S
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142864/
https://ncbi.nlm.nih.gov/pubmed/29982679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwy061
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