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Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue

Adipose tissue macrophages (ATMs) adapt their metabolic phenotype either to maintain lean tissue homeostasis or drive inflammation and insulin resistance in obesity. However, the factors in the adipose tissue microenvironment that control ATM phenotypic polarization and bioenergetics remain unknown....

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Serbulea, Vlad, Upchurch, Clint M., Schappe, Michael S., Voigt, Paxton, DeWeese, Dory E., Desai, Bimal N., Meher, Akshaya K., Leitinger, Norbert
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142199/
https://ncbi.nlm.nih.gov/pubmed/29891687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800544115
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