Hesperetin Prevents Bone Resorption by Inhibiting RANKL-Induced Osteoclastogenesis and Jnk Mediated Irf-3/c-Jun Activation

Bone homeostasis and resorption is regulated by the proper activation of osteoclasts, whose stimulation largely depends on the receptor activator of nuclear factor κB ligand (RANKL)-RANK signaling. Herein, for the first time, we showed that interferon regulatory factor (Irf)-3 was intimately involve...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Zhang, Qiang, Tang, Xinqiao, Liu, Zhong, Song, Xiaoxia, Peng, Dan, Zhu, Wei, Ouyang, Zhengxiao, Wang, Wanchun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142014/
https://ncbi.nlm.nih.gov/pubmed/30254586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01028
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