Using vaccine Immunostimulation/Immunodynamic modelling methods to inform vaccine dose decision-making

Unlike drug dose optimisation, mathematical modelling has not been applied to vaccine dose finding. We applied a novel Immunostimulation/Immunodynamic mathematical modelling framework to translate multi-dose TB vaccine immune responses from mice, to predict most immunogenic dose in humans. Data were...

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Vydáno v:NPJ Vaccines
Hlavní autoři: Rhodes, Sophie J., Guedj, Jeremie, Fletcher, Helen A., Lindenstrøm, Thomas, Scriba, Thomas J., Evans, Thomas G., Knight, Gwenan M., White, Richard G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141590/
https://ncbi.nlm.nih.gov/pubmed/30245860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-018-0075-3
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