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β-Subunit of the voltage-gated Ca(2+) channel Cav1.2 drives signaling to the nucleus via H-Ras

Depolarization-induced signaling to the nucleus by the L-type voltage-gated calcium channel Cav1.2 is widely assumed to proceed by elevating intracellular calcium. The apparent lack of quantitative correlation between Ca(2+) influx and gene activation suggests an alternative activation pathway. Here...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Servili, Evrim, Trus, Michael, Maayan, Daphne, Atlas, Daphne
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140482/
https://ncbi.nlm.nih.gov/pubmed/30150369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805380115
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