Nano LC-MS using capillary columns enables accurate quantification of modified ribonucleosides at low femtomol levels

Post-transcriptional chemical modifications of (t)RNA molecules are crucial in fundamental biological processes, such as translation. Despite their biological importance and accumulating evidence linking them to various human diseases, technical challenges have limited their detection and accurate q...

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Detalhes bibliográficos
Publicado no:RNA
Main Authors: Sarin, L. Peter, Kienast, Sandra D., Leufken, Johannes, Ross, Robert L., Dziergowska, Agnieszka, Debiec, Katarzyna, Sochacka, Elzbieta, Limbach, Patrick A., Fufezan, Christian, Drexler, Hannes C.A., Leidel, Sebastian A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
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Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140458/
https://ncbi.nlm.nih.gov/pubmed/30012570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.065482.117
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