The Iron-Klotho-VDR Axis Is a Major Determinant of Proximal Convoluted Tubule Injury in Haptoglobin 2-2 Genotype Diabetic Nephropathy Patients and Mice

The haptoglobin (Hp) genotype (1-1 and 2-2) is a major determinant of nephropathy progression in diabetes mellitus patients. Hp 2-2 diabetic mice have impaired Hb clearance and increased iron deposits and oxidative stress in the proximal tubules (PCT), leading to increased renal injury. However, the...

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Bibliographic Details
Published in:J Diabetes Res
Main Authors: Dahan, Inbal, Thawho, Nadia, Farber, Evgeny, Nakhoul, Nakhoul, Asleh, Rabea, Levy, Andrew P., Li, Yan Chun, Ben-Izhak, Ofer, Nakhoul, Farid
Format: Artigo
Language:Inglês
Published: Hindawi 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140001/
https://ncbi.nlm.nih.gov/pubmed/30250850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/7163652
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