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Iron-dependent cleavage of ribosomal RNA during oxidative stress in the yeast Saccharomyces cerevisiae

Stress-induced strand breaks in rRNA have been observed in many organisms, but the mechanisms by which they originate are not well-understood. Here we show that a chemical rather than an enzymatic mechanism initiates rRNA cleavages during oxidative stress in yeast (Saccharomyces cerevisiae). We used...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zinskie, Jessica A., Ghosh, Arnab, Trainor, Brandon M., Shedlovskiy, Daniel, Pestov, Dimitri G., Shcherbik, Natalia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139556/
https://ncbi.nlm.nih.gov/pubmed/30021840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004174
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