Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue

Obesity and the metabolic syndrome are characterized by chronic, low-grade inflammation mainly originating from expanding adipose tissue and resulting in inhibition of insulin signaling and disruption of glycemic control. Transgenic mice expressing human interleukin 37 (IL-37), an anti-inflammatory...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Ballak, Dov B., Li, Suzhao, Cavalli, Giulio, Stahl, Jonathan L., Tengesdal, Isak W., van Diepen, Janna A., Klück, Viola, Swartzwelter, Benjamin, Azam, Tania, Tack, Cees J., Stienstra, Rinke, Mandrup-Poulsen, Thomas, Seals, Douglas R., Dinarello, Charles A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139546/
https://ncbi.nlm.nih.gov/pubmed/30006351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003698
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