Conversion of all-trans-retinal into all-trans-retinal dimer reflects an alternative metabolic/antidotal pathway of all-trans-retinal in the retina

Free all-trans-retinal (atRAL) and retinal pigment epithelium (RPE) lipofuscin are both considered to play etiological roles in Stargardt disease and age-related macular degeneration. A2E and all-trans-retinal dimer (atRAL-dimer) are two well characterized bisretinoid constituents of RPE lipofuscin....

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Gao, Zhan, Liao, Yi, Chen, Chao, Liao, Chunyan, He, Danxue, Chen, Jingmeng, Ma, Jianxing, Liu, Zuguo, Wu, Yalin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2018
Onderwerpen:
Metabolism
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139543/
https://ncbi.nlm.nih.gov/pubmed/30049796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002447
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