Role of WNK4 and kidney-specific WNK1 in mediating the effect of high dietary K(+) intake on ROMK channel in the distal convoluted tubule

With-no-lysine kinase 4 (WNK4) and kidney-specific (KS)-WNK1 regulate ROMK (Kir1.1) channels in a variety of cell models. We now explore the role of WNK4 and KS-WNK1 in regulating ROMK in the native distal convoluted tubule (DCT)/connecting tubule (CNT) by measuring tertiapin-Q (TPNQ; ROMK inhibitor...

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Bibliografske podrobnosti
izdano v:Am J Physiol Renal Physiol
Main Authors: Wu, Peng, Gao, Zhong-Xiuzi, Su, Xiao-Tong, Ellison, David H., Hadchouel, Juliette, Teulon, Jacques, Wang, Wen-Hui
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139523/
https://ncbi.nlm.nih.gov/pubmed/29667910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00050.2018
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