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Loss of biliverdin reductase-A promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells

Obesity and increased lipid availability have been implicated in the development and progression of chronic kidney disease. One of the major sites of renal lipid accumulation is in the proximal tubule cells of the kidney, suggesting that these cells may be susceptible to lipotoxicity. We previously...

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Publicat a:Am J Physiol Renal Physiol
Autors principals: Adeosun, Samuel O., Gordon, Darren M., Weeks, Mary Frances, Moore, Kyle H., Hall, John E., Hinds, Terry D., Stec, David E.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139518/
https://ncbi.nlm.nih.gov/pubmed/29631357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00495.2017
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