Prevalence of PDL1 Amplification and Preliminary Response to Immune Checkpoint Blockade in Solid Tumors

IMPORTANCE: Copy number alterations in programmed cell death ligand 1 (PDL1 or CD274), programmed cell death 1 ligand 2 (PDCD1LG2 or PDL2), and Janus kinase 2 (JAK2) genes (chromosome 9p24.1) characterize Hodgkin lymphoma, resulting in high response rates to programmed cell death 1 (PD-1)/programmed...

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Detalhes bibliográficos
Publicado no:JAMA Oncol
Main Authors: Goodman, Aaron M., Piccioni, David, Kato, Shumei, Boichard, Amélie, Wang, Huan-You, Frampton, Garrett, Lippman, Scott M., Connelly, Caitlin, Fabrizio, David, Miller, Vincent, Sicklick, Jason K., Kurzrock, Razelle
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2018
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139049/
https://ncbi.nlm.nih.gov/pubmed/29902298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2018.1701
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