Spliceosome Mutations Induce R loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndrome

Heterozygous somatic mutations in spliceosome genes (U2AF1, SF3B1, ZRSR2, or SRSF2) occur in >50% of myelodysplastic syndrome (MDS) patients. These mutations occur early in disease development, suggesting that they contribute to MDS pathogenesis and may represent a unique genetic vulnerability fo...

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Publicado en:Cancer Res
Main Authors: Nguyen, Hai Dang, Leong, Wan Yee, Li, Weiling, Reddy, Pavankumar N. G., Sullivan, Jack D., Walter, Matthew J., Zou, Lee, Graubert, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139047/
https://ncbi.nlm.nih.gov/pubmed/30054334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-3970
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