Reduced intrinsic DNA curvature leads to increased mutation rate

BACKGROUND: Mutation rates vary across the genome. Many trans factors that influence mutation rates have been identified, as have specific sequence motifs at the 1–7-bp scale, but cis elements remain poorly characterized. The lack of understanding regarding why different sequences have different mut...

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Detalles Bibliográficos
Publicado en:Genome Biol
Main Authors: Duan, Chaorui, Huan, Qing, Chen, Xiaoshu, Wu, Shaohuan, Carey, Lucas B., He, Xionglei, Qian, Wenfeng
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2018
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138893/
https://ncbi.nlm.nih.gov/pubmed/30217230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1525-y
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