3-Chloro-N′-(2-hydroxybenzylidene) benzohydrazide: An LSD1-Selective Inhibitor and Iron-Chelating Agent for Anticancer Therapy

Despite the discovery and development of novel therapies, cancer is still a leading cause of death worldwide. In order to grow, tumor cells require large quantities of nutrients involved in metabolic processes, and an increase in iron levels is known to contribute to cancer proliferation. Iron plays...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Sarno, Federica, Papulino, Chiara, Franci, Gianluigi, Andersen, Jeanette H., Cautain, Bastien, Melardo, Colombina, Altucci, Lucia, Nebbioso, Angela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137965/
https://ncbi.nlm.nih.gov/pubmed/30245629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01006
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