Research on the mechanism of drug–drug interaction between salvianolate injection and aspirin based on the metabolic enzyme and PK-PD model: study protocol for a PK-PD trial

BACKGROUND: Coronary heart disease (CHD) is a common cardiovascular disease accounting for 10–20% mortality by heart disease worldwide. The gold standard treatment to manage CHD is aspirin, which may prevent myocardial infarction and sudden death; however, long-term use of aspirin may increase its s...

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Publicado en:Trials
Autores principales: Zhang, Wantong, Zhu, Baochen, Cao, Weiyi, Li, Rui, Wang, Shuge, Gao, Rui
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
Materias:
Study Protocol
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137745/
https://ncbi.nlm.nih.gov/pubmed/30217228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-018-2861-7
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