Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma

The substantial rise in the prevalence of nonalcoholic steatohepatitis (NASH), an advanced form of nonalcoholic fatty liver disease, and the strong association between NASH and the development of hepatocellular carcinoma indicate the urgent need for a better understanding of the underlying mechanism...

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Vydáno v:FASEB J
Hlavní autoři: Pogribny, Igor P., Dreval, Kostiantyn, Kindrat, Iryna, Melnyk, Stepan, Jimenez, Leandro, de Conti, Aline, Tryndyak, Volodymyr, Pogribna, Marta, Ortega, Juliana Festa, James, S. Jill, Rusyn, Ivan, Beland, Frederick A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137451/
https://ncbi.nlm.nih.gov/pubmed/29127188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700866R
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