Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma

The substantial rise in the prevalence of nonalcoholic steatohepatitis (NASH), an advanced form of nonalcoholic fatty liver disease, and the strong association between NASH and the development of hepatocellular carcinoma indicate the urgent need for a better understanding of the underlying mechanism...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Pogribny, Igor P., Dreval, Kostiantyn, Kindrat, Iryna, Melnyk, Stepan, Jimenez, Leandro, de Conti, Aline, Tryndyak, Volodymyr, Pogribna, Marta, Ortega, Juliana Festa, James, S. Jill, Rusyn, Ivan, Beland, Frederick A.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137451/
https://ncbi.nlm.nih.gov/pubmed/29127188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700866R
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