Ulinastatin Inhibits Osteoclastogenesis and Suppresses Ovariectomy-Induced Bone Loss by Downregulating uPAR

Recent studies indicate that uPAR acts a crucial part in cell migration and the modulation of bone homeostasis. As a natural serine protease inhibitor, ulinastatin owns the capacity to reduce proinflammatory factors, downregulate the activation of NF-κB and mitogen-activated protein kinases (MAPKs)...

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Publicado en:Front Pharmacol
Autores principales: Huang, Jun-ming, Ren, Ran-yue, Bao, Yuan, Guo, Jia-chao, Xiang, Wei, Jing, Xing-zhi, Shi, Jia, Zhang, Guo-xiang, Li, Long, Tian, Yong, Kang, Hao, Guo, Feng-jin
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137085/
https://ncbi.nlm.nih.gov/pubmed/30245631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01016
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