Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival

Pancreatic ductal adenocarcinoma (PDAC) has reactive stroma that promotes tumor signaling, fibrosis, inflammation, and hypoxia, which activates HIF-1α to increase tumor cell metastasis and therapeutic resistance. Carbonic anhydrase IX (CA9) stabilizes intracellular pH following induction by HIF-1α....

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Bibliographic Details
Published in:Sci Rep
Main Authors: Logsdon, Derek P., Shah, Fenil, Carta, Fabrizio, Supuran, Claudiu T., Kamocka, Malgorzata, Jacobsen, Max H., Sandusky, George E., Kelley, Mark R., Fishel, Melissa L.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137035/
https://ncbi.nlm.nih.gov/pubmed/30214007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32034-9
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