Association of BRCA2 K3326* With Small Cell Lung Cancer and Squamous Cell Cancer of the Skin

BACKGROUND: Most pathogenic mutations in the BRCA2 gene carry a high risk of hereditary breast and ovarian cancer (HBOC). However, a stop-gain mutation, K3326* (rs11571833), confers risk of lung cancer and cancers of the upper-aero-digestive tract but only a modest risk of breast or ovarian cancer....

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Pubblicato in:J Natl Cancer Inst
Autori principali: Rafnar, Thorunn, Sigurjonsdottir, Gudbjorg R, Stacey, Simon N, Halldorsson, Gisli, Sulem, Patrick, Pardo, Luba M, Helgason, Hannes, Sigurdsson, Stefan T, Gudjonsson, Thorkell, Tryggvadottir, Laufey, Olafsdottir, Gudridur H, Jonasson, Jon G, Alexiusdottir, Kristin, Sigurdsson, Asgeir, Gudmundsson, Julius, Saemundsdottir, Jona, Sigurdsson, Jon K, Johannsdottir, Hrefna, Uitterlinden, Andre, Vermeulen, Sita H, Galesloot, Tessel E, Allain, Dawn C, Lacko, Martin, Sigurgeirsson, Bardur, Thorisdottir, Kristin, Johannsson, Oskar T, Sigurdsson, Fridbjorn, Ragnarsson, Gunnar B, Isaksson, Helgi, Hardardottir, Hronn, Gudbjartsson, Tomas, Gudbjartsson, Daniel F, Masson, Gisli, Kiemeney, Lambertus A M L, Ewart Toland, Amanda, Nijsten, Tamar, Peters, Wilbert H M, Olafsson, Jon H, Jonsson, Steinn, Thorsteinsdottir, Unnur, Thorleifsson, Gudmar, Stefansson, Kari
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6136924/
https://ncbi.nlm.nih.gov/pubmed/29767749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djy002
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