Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri

Naegleria fowleri is a free-living amoeba that can also act as an opportunistic pathogen causing severe brain infection, primary amebic meningoencephalitis (PAM), in humans. The high mortality rate of PAM (exceeding 97%) is attributed to (i) delayed diagnosis, (ii) lack of safe and effective anti-N....

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Pubblicato in:PLoS Pathog
Autori principali: Zhou, Wenxu, Debnath, Anjan, Jennings, Gareth, Hahn, Hye Jee, Vanderloop, Boden H., Chaudhuri, Minu, Nes, W. David, Podust, Larissa M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6136796/
https://ncbi.nlm.nih.gov/pubmed/30212566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007245
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