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Identification of four amoebicidal non-toxic compounds by a molecular docking screen of Naegleria fowleri sterol Δ8−Δ7-isomerase and phenotypic assays

Naegleria fowleri is a free-living amoeba causing primary amoebic meningoencephalitis, a rapid-onset brain infection in humans with over 97% mortality rate. Despite some progress in the treatment of the disease, there is no single, proven, evidence-based treatment with a high probability of cure. He...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Shi, Da, Chahal, Kirti Kandhwal, Oto, Patricia, Nothias, Louis-Felix, Debnath, Anjan, McKerrow, James H., Podust, Larissa M., Abagyan, Ruben
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7085920/
https://ncbi.nlm.nih.gov/pubmed/31583882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.9b00227
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