PPARα-mediated peroxisome induction compensates PPARγ-deficiency in bronchiolar club cells

Despite the important functions of PPARγ in various cell types of the lung, PPARγ-deficiency in club cells induces only mild emphysema. Peroxisomes are distributed in a similar way as PPARγ in the lung and are mainly enriched in club and AECII cells. To date, the effects of PPARγ-deficiency on the o...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Karnati, Srikanth, Oruqaj, Gani, Janga, Harshavardhan, Tumpara, Srinu, Colasante, Claudia, Van Veldhoven, Paul P., Braverman, Nancy, Pilatz, Adrian, Mariani, Thomas J., Baumgart-Vogt, Eveline
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6136741/
https://ncbi.nlm.nih.gov/pubmed/30212482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203466
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