Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling

Idiopathic pulmonary fibrosis (IPF) is a devastating disease, and its pathogenic mechanisms remain incompletely understood. Peroxisomes are known to be important in ROS and proinflammatory lipid degradation, and their deficiency induces liver fibrosis. However, altered peroxisome functions in IPF pa...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Oruqaj, Gani, Karnati, Srikanth, Vijayan, Vijith, Kotarkonda, Lakshmi Kanth, Boateng, Eistine, Zhang, Wenming, Ruppert, Clemens, Günther, Andreas, Shi, Wei, Baumgart-Vogt, Eveline
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413321/
https://ncbi.nlm.nih.gov/pubmed/25848047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415111112
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