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A Large-Scale Gene Expression Intensity-Based Similarity Metric for Drug Repositioning
Biological systems often respond to a specific environmental or genetic perturbation without pervasive gene expression changes. Such robustness to perturbations, however, is not reflected on the current computational strategies that utilize gene expression similarity metrics for drug discovery and r...
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Publicado no: | iScience |
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Main Authors: | , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Elsevier
2018
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6135902/ https://ncbi.nlm.nih.gov/pubmed/30267685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.08.017 |
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