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A Large-Scale Gene Expression Intensity-Based Similarity Metric for Drug Repositioning

Biological systems often respond to a specific environmental or genetic perturbation without pervasive gene expression changes. Such robustness to perturbations, however, is not reflected on the current computational strategies that utilize gene expression similarity metrics for drug discovery and r...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Huang, Chen-Tsung, Hsieh, Chiao-Hui, Oyang, Yen-Jen, Huang, Hsuan-Cheng, Juan, Hsueh-Fen
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135902/
https://ncbi.nlm.nih.gov/pubmed/30267685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.08.017
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