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A microfluidic device for isolating intact chromosomes from single mammalian cells and probing their folding stability by controlling solution conditions
Chromatin folding shows spatio-temporal fluctuations in living undifferentiated cells, but fixed spatial heterogeneity in differentiated cells. However, little is known about variation in folding stability along the chromatin fibres during differentiation. In addition, effective methods to investiga...
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| Gepubliceerd in: | Sci Rep |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group UK
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6135817/ https://ncbi.nlm.nih.gov/pubmed/30209290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31975-5 |
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