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Striatal dopamine D2 receptors regulate effort but not value-based decision making and alter the dopaminergic encoding of cost

Deficits in goal-directed motivation represent a debilitating symptom for many patients with schizophrenia. Impairments in motivation can arise from deficits in processing information about effort and or value, disrupting effective cost-benefit decision making. We have previously shown that upregula...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Filla, Ina, Bailey, Matthew R., Schipani, Elke, Winiger, Vanessa, Mezias, Chris, Balsam, Peter D., Simpson, Eleanor H.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135745/
https://ncbi.nlm.nih.gov/pubmed/30082890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0159-9
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