Alendronate-induced disruption of actin cytoskeleton and inhibition of migration/invasion are associated with cofilin downregulation in PC-3 prostate cancer cells

Bisphosphonates are used for prevention of osteoporosis and metastatic bone diseases. Anti-invasive effects on various cancer cells have also been reported, but the mechanisms involved are not well-understood. We investigated the effects of the nitrogen-containing bisphosphonate alendronate (ALN) on...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Virtanen, Sanna S., Ishizu, Tamiko, Sandholm, Jouko A., Löyttyniemi, Eliisa, Väänänen, H. Kalervo, Tuomela, Johanna M., Härkönen, Pirkko L.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2018
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135693/
https://ncbi.nlm.nih.gov/pubmed/30220968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25961
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