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Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships (RASAR) Outperforming Animal Test Reproducibility

Earlier we created a chemical hazard database via natural language processing of dossiers submitted to the European Chemical Agency with approximately 10 000 chemicals. We identified repeat OECD guideline tests to establish reproducibility of acute oral and dermal toxicity, eye and skin irritation,...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Luechtefeld, Thomas, Marsh, Dan, Rowlands, Craig, Hartung, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135638/
https://ncbi.nlm.nih.gov/pubmed/30007363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy152
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