Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival

Acute myeloid leukemia (AML) with an NPM1 mutation (NPMc+) has a distinct gene expression signature and displays molecular abnormalities similar to mixed lineage leukemia (MLL), including aberrant expression of the PBX3 and HOXA gene cluster. However, it is unclear if the aberrant expression of PBX3...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Zhang, Wu, Zhao, Chen, Zhao, Junmei, Zhu, Yongmei, Weng, Xiangqin, Chen, Qiusheng, Sun, Huiping, Mi, Jian-Qing, Li, Junmin, Zhu, Jiang, Chen, Zhu, Pandolfi, Pier Paolo, Chen, Saijuan, Yan, Xiaojing, Xu, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134928/
https://ncbi.nlm.nih.gov/pubmed/30214626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.26900
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