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Preserving prion strain identity upon replication of prions in vitro using recombinant prion protein

Last decade witnessed an enormous progress in generating authentic infectious prions or PrP(Sc) in vitro using recombinant prion protein (rPrP). Previous work established that rPrP that lacks posttranslational modification is able to support replication of highly infectious PrP(Sc) with assistance o...

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Detalles Bibliográficos
Publicado en:Acta Neuropathol Commun
Main Authors: Makarava, Natallia, Savtchenko, Regina, Lasch, Peter, Beekes, Michael, Baskakov, Ilia V.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134792/
https://ncbi.nlm.nih.gov/pubmed/30208966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0597-y
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