Optimization of the Linker Length of Mannose-Cholesterol Conjugates for Enhanced mRNA Delivery to Dendritic Cells by Liposomes

Liposomes (LPs) as commonly used mRNA delivery systems remain to be rationally designed and optimized to ameliorate the antigen expression of mRNA vaccine in dendritic cells (DCs). In this study, we synthesized mannose-cholesterol conjugates (MP(n)-CHs) by click reaction using different PEG units (P...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Wang, Fazhan, Xiao, Wen, Elbahnasawy, Mostafa A., Bao, Xingting, Zheng, Qian, Gong, Linhui, Zhou, Yang, Yang, Shuping, Fang, Aiping, Farag, Mohamed M. S., Wu, Jinhui, Song, Xiangrong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134263/
https://ncbi.nlm.nih.gov/pubmed/30233368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00980
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