Targeting myeloid-derived suppressor cells using all-trans retinoic acid in melanoma patients treated with Ipilimumab.

BACKGROUND: Immune checkpoint inhibitors have improved overall survival rates for many cancers, yet the majority of patients do not respond to treatment and succumb to disease progression. One tumor-related mechanism limiting the efficacy of immunotherapies in melanoma is the recruitment and expansi...

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Vydáno v:Int Immunopharmacol
Hlavní autoři: Tobin, Richard P., Jordan, Kimberly R., Robinson, William A., Davis, Dana, Borges, Virginia F., Gonzalez, Rene, Lewis, Karl D., McCarter, Martin D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134177/
https://ncbi.nlm.nih.gov/pubmed/30121453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.intimp.2018.08.007
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