MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12

Chondrocyte loss is a prominent feature of osteoarthritis (OA). Autophagy is indispensable in maintaining the metabolic activities of cells exposed to deleterious stress. The contribution of microRNA signaling to chondrocyte autophagy in OA development remains elusive. We uncovered an association be...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Lian, Wei-Shiung, Ko, Jih-Yang, Wu, Re-Weng, Sun, Yi-Chih, Chen, Yu-Shan, Wu, Shin-Long, Weng, Lin-Hsiu, Jahr, Holger, Wang, Feng-Sheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134128/
https://ncbi.nlm.nih.gov/pubmed/30206206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0994-y
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