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Glucosylceramide modifies the LPS-induced inflammatory response in macrophages and the orientation of the LPS/TLR4 complex in silico

Toll-like receptor 4 (TLR4) is activated by bacterial lipopolysaccharide (LPS), which drives the production of proinflammatory cytokines. Earlier studies have indicated that cholesterol- and glycosphingolipid-rich subregions of the plasma membrane (lipid domains) are important for TLR4-mediated sign...

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Udgivet i:Sci Rep
Main Authors: Mobarak, Edouard, Håversen, Liliana, Manna, Moutusi, Rutberg, Mikael, Levin, Malin, Perkins, Rosie, Rog, Tomasz, Vattulainen, Ilpo, Borén, Jan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134110/
https://ncbi.nlm.nih.gov/pubmed/30206272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31926-0
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