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Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia

Ceramide synthases (CERS) produce ceramides which are key intermediators in the biosynthesis of complex sphingolipids and play an important role in cell proliferation, differentiation, apoptosis and senescence. CERS6 is an isoform of ceramide synthases known to generate ceramides with C16 acyl chain...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Verlekar, Dattesh, Wei, Sung-Jen, Cho, Hwangeui, Yang, Shengping, Kang, Min H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6133972/
https://ncbi.nlm.nih.gov/pubmed/30206207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0964-4
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