By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, Stichoposide D inhibits growth of leukemia xenografts

Stichoposide D (STD) is a marine triterpene glycoside isolated from sea cucumbers. We examined the molecular mechanisms underlying the antitumor activity of STD in human leukemia cells. The role of Fas (CD95), ceramide synthase 6 (CerS6) and p38 kinase during STD-induced apoptosis was examined in hu...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Yun, Seong-Hoon, Park, Eun-Seon, Shin, Sung-Won, Ju, Mi-Ha, Han, Jin-Yeong, Jeong, Jin-Sook, Kim, Sung-Hyun, Stonik, Valentin A., Kwak, Jong-Young, Park, Joo-In
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695011/
https://ncbi.nlm.nih.gov/pubmed/26318294
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