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Design of non-inferiority randomized trials using the difference in Restricted Mean Survival Times

BACKGROUND/AIMS: Non-inferiority trials with time-to-event outcomes are becoming increasingly common. Designing non-inferiority trials is challenging, in particular, they require very large sample sizes. We hypothesized that the difference in restricted mean survival time, an alternative to the haza...

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Bibliographische Detailangaben
Veröffentlicht in:Clin Trials
Hauptverfasser: Weir, Isabelle R, Trinquart, Ludovic
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6133762/
https://ncbi.nlm.nih.gov/pubmed/30074407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774518792259
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