Optineurin E50K triggers BDNF deficiency-mediated mitochondrial dysfunction in retinal photoreceptor cell line

Optineurin (OPTN) mutations are linked to glaucoma pathology and E50K mutation shows massive cell death in photoreceptor cells and retinal ganglion cells. However, little is known about E50K-mediated mitochondrial dysfunction in photoreceptor cell degeneration. We here show that overexpression of E5...

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Publicat a:Biochem Biophys Res Commun
Autors principals: Shim, Myoung Sup, Kim, Keun-Young, Noh, Mark, Ko, Ji Yoon, Ahn, Sangphil, An, Michelle A., Iwata, Takeshi, Perkins, Guy A., Weinreb, Robert N., Ju, Won-Kyu
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6133749/
https://ncbi.nlm.nih.gov/pubmed/30100066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.08.025
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