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Revisiting isotonic phase I design in the era of model-assisted dose-finding
BACKGROUND/AIMS: In the conduct of phase I trials, the limited use of innovative model-based designs in practice has led to an introduction of a class of “model-assisted” designs with the aim of effectively balancing the trade-off between design simplicity and performance. Prior to the recent surge...
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| Pubblicato in: | Clin Trials |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6133737/ https://ncbi.nlm.nih.gov/pubmed/30101616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774518792258 |
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