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In Vivo Red Blood Cells/Plasma Partition Coefficient of Treosulfan and Its Active Monoepoxide in Rats

BACKGROUND AND OBJECTIVES: Treosulfan is a prodrug applied in the treatment of ovarian cancer and conditioning prior to stem cell transplantation. So far, the bioanalysis of treosulfan in either whole blood or red blood cells (RBC) has not been carried out. In this work, the RBC/plasma partition coe...

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Bibliografiske detaljer
Udgivet i:Eur J Drug Metab Pharmacokinet
Main Authors: Romański, Michał, Zacharzewska, Anna, Teżyk, Artur, Główka, Franciszek K.
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6133075/
https://ncbi.nlm.nih.gov/pubmed/29542019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13318-018-0469-7
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