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Calibration and validation of toxicokinetic-toxicodynamic models for three neonicotinoids and some aquatic macroinvertebrates

Exposure patterns in ecotoxicological experiments often do not match the exposure profiles for which a risk assessment needs to be performed. This limitation can be overcome by using toxicokinetic-toxicodynamic (TKTD) models for the prediction of effects under time-variable exposure. For the use of...

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Detalhes bibliográficos
Publicado no:Ecotoxicology
Main Authors: Focks, Andreas, Belgers, Dick, Boerwinkel, Marie-Claire, Buijse, Laura, Roessink, Ivo, Van den Brink, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132984/
https://ncbi.nlm.nih.gov/pubmed/29717389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10646-018-1940-6
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