Monosodium urate crystals reduce osteocyte viability and indirectly promote a shift in osteocyte function towards a proinflammatory and proresorptive state

BACKGROUND: Bone erosion is a frequent complication of gout and is strongly associated with tophi, which are lesions comprising inflammatory cells surrounding collections of monosodium urate (MSU) crystals. Osteocytes are important cellular mediators of bone remodeling. The aim of this study was to...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Chhana, Ashika, Pool, Bregina, Callon, Karen E., Tay, Mei Lin, Musson, David, Naot, Dorit, McCarthy, Geraldine, McGlashan, Susan, Cornish, Jillian, Dalbeth, Nicola
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131786/
https://ncbi.nlm.nih.gov/pubmed/30201038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1704-y
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