Monosodium urate crystals reduce osteocyte viability and indirectly promote a shift in osteocyte function towards a proinflammatory and proresorptive state

BACKGROUND: Bone erosion is a frequent complication of gout and is strongly associated with tophi, which are lesions comprising inflammatory cells surrounding collections of monosodium urate (MSU) crystals. Osteocytes are important cellular mediators of bone remodeling. The aim of this study was to...

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Bibliografiske detaljer
Udgivet i:Arthritis Res Ther
Main Authors: Chhana, Ashika, Pool, Bregina, Callon, Karen E., Tay, Mei Lin, Musson, David, Naot, Dorit, McCarthy, Geraldine, McGlashan, Susan, Cornish, Jillian, Dalbeth, Nicola
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131786/
https://ncbi.nlm.nih.gov/pubmed/30201038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1704-y
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