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Fluorogenic structure activity library pinpoints molecular variations in substrate specificity of structurally homologous esterases

Cellular esterases catalyze many essential biological functions by performing hydrolysis reactions on diverse substrates. The promiscuity of esterases complicates assignment of their substrate preferences and biological functions. To identify universal factors controlling esterase substrate recognit...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: White, Alex, Koelper, Andrew, Russell, Arielle, Larsen, Erik M., Kim, Charles, Lavis, Luke D., Hoops, Geoffrey C., Johnson, R. Jeremy
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130942/
https://ncbi.nlm.nih.gov/pubmed/30006352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003972
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